Best Performing ETFs
Choose the period and basis. Price return uses closing prices; total return uses the dividend-adjusted series (distributions reinvested). Multi-year figures are annualized. Funds under $50M excluded.
Sparklines show the trailing 12 months of dividend-adjusted closes, through Oct 19, 2026.
| # | ETF | Price | Today | 1Y trend | Period Return | AUM | Expense | YTD | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | IDNA iShares Genomics Immunology and Healthcare ETF | 42.58 | +3.96% | +66.44% | $311.0M | 0.47% | +56.40% | ||
| 2 | GNOM Global X - Genomics & Biotechnology ETF | 67.65 | +3.16% | +53.55% | $107.3M | 0.50% | +44.26% | ||
| 3 | ARKG ARK Genomic Revolution ETF | 48.65 | +2.70% | +52.81% | $2.22B | 0.75% | +63.51% | ||
| 4 | FTXH First Trust Nasdaq Pharmaceuticals ETF | 42.70 | +2.68% | +42.64% | $1.10B | 0.60% | +26.27% | ||
| 5 | BBP Virtus Biotech ETF | 105.80 | +3.34% | +42.10% | $127.7M | 0.34% | +28.12% | ||
| 6 | FBT First Trust NYSE Arca Biotechnology Index Fund | 271.77 | +2.37% | +41.28% | $2.92B | 0.55% | +28.55% | ||
| 7 | XBI State Street SPDR S&P Biotech ETF | 153.24 | +3.64% | +37.16% | $9.88B | 0.35% | +21.27% | ||
| 8 | BBH VanEck Biotech ETF | 248.78 | +3.17% | +36.51% | $488.1M | 0.35% | +27.41% | ||
| 9 | IHE iShares U.S. Pharmaceuticals ETF | 103.47 | +2.87% | +35.39% | $1.56B | 0.37% | +18.57% | ||
| 10 | XHS State Street SPDR S&P Health Care Services ETF | 141.19 | +2.61% | +35.24% | $213.1M | 0.35% | +28.70% | ||
| 11 | HTEC ROBO Global Healthcare Technology and… | 44.06 | +2.62% | +34.07% | $107.1M | 0.80% | +21.55% | ||
| 12 | PBE Invesco Biotechnology & Genome ETF | 99.31 | +2.69% | +33.99% | $419.7M | 0.59% | +17.81% | ||
| 13 | CANC Tema Oncology ETF | 41.59 | +3.94% | +32.81% | $202.6M | 0.99% | +15.25% | ||
| 14 | IBB iShares Biotechnology ETF | 210.50 | +3.16% | +32.34% | $10.51B | 0.44% | +20.91% | ||
| 15 | IBBQ Invesco Nasdaq Biotechnology ETF | 35.17 | +3.44% | +31.53% | $110.9M | 0.19% | +19.72% | ||
| 16 | PJP Invesco Pharmaceuticals ETF | 126.41 | +2.34% | +31.30% | $548.3M | 0.58% | +18.15% | ||
| 17 | XPH State Street SPDR S&P Pharmaceuticals ETF | 64.15 | +3.07% | +29.13% | $438.6M | 0.35% | +11.12% | ||
| 18 | RSPH Invesco S&P 500 Equal Weight Health Care ETF | 39.37 | +1.78% | +28.33% | $939.8M | 0.40% | +21.44% | ||
| 19 | PSCH Invesco S&P SmallCap Health Care ETF | 53.74 | +2.33% | +24.43% | $169.5M | 0.29% | +19.20% | ||
| 20 | PTH Invesco Dorsey Wright Healthcare Momentum ETF | 58.84 | +3.45% | +23.72% | $277.0M | 0.74% | +14.44% | ||
| 21 | PPH VanEck Pharmaceutical ETF | 116.34 | +2.52% | +23.56% | $1.08B | 0.36% | +9.99% | ||
| 22 | SBIO ALPS Medical Breakthroughs ETF | 54.81 | +5.18% | +23.51% | $180.0M | 0.50% | +1.74% | ||
| 23 | XLV State Street Health Care Select Sector SPDR… | 179.82 | +2.37% | +22.60% | $46.07B | 0.08% | +13.47% | ||
| 24 | FHLC Fidelity MSCI Health Care Index ETF | 86.30 | +2.43% | +22.28% | $3.54B | 0.08% | +13.42% | ||
| 25 | IYH iShares U.S. Healthcare ETF | 75.52 | +2.34% | +22.21% | $4.48B | 0.37% | +13.35% | ||
| 26 | VHT Vanguard Health Care ETF | 333.60 | +2.35% | +21.85% | $21.80B | 0.09% | +13.23% | ||
| 27 | FXH First Trust Health Care AlphaDEX Fund | 135.05 | +1.99% | +18.58% | $1.12B | 0.61% | +16.33% | ||
| 28 | FMED Fidelity Disruptive Medicine ETF | 31.75 | +3.16% | +18.06% | $52.3M | 0.50% | +13.79% | ||
| 29 | PINK Simplify Health Care ETF | 39.48 | +2.43% | +17.72% | $318.0M | 0.51% | +5.30% | ||
| 30 | IHF iShares U.S. Healthcare Providers ETF | 60.32 | +2.50% | +16.74% | $1.40B | 0.37% | +22.76% | ||
| 31 | IXJ iShares Global Healthcare ETF | 109.10 | +2.51% | +16.00% | $4.61B | 0.38% | +9.27% | ||
| 32 | HRTS Tema Heart & Health ETF | 37.75 | +2.30% | +14.37% | $54.7M | 0.99% | +4.55% | ||
| 33 | XHE State Street SPDR S&P Health Care Equipment… | 91.78 | +1.94% | +13.25% | $146.3M | 0.35% | +2.04% | ||
| 34 | AGNG Global X - Aging Population ETF | 38.11 | +2.32% | +9.03% | $90.7M | 0.50% | +3.75% | ||
| 35 | OZEM Roundhill Investments - GLP-1 & Weight Loss… | 30.21 | +3.89% | +4.60% | $56.4M | 0.59% | -14.87% | ||
| 36 | IHI iShares U.S. Medical Devices ETF | 54.27 | +0.95% | -10.13% | $3.46B | 0.37% | -13.50% | ||
| 37 | KURE KraneShares MSCI All China Health Care Index… | 18.18 | +3.00% | -10.18% | $113.8M | 0.79% | +3.58% | ||
| 38 | MSOS AdvisorShares Pure US Cannabis ETF | 3.99 | +4.72% | -19.96% | $724.1M | 0.81% | -19.28% | ||
| 39 | CNBS Amplify Seymour Cannabis ETF | 23.19 | +3.13% | -22.51% | $61.5M | 1.09% | -19.81% | ||
| 40 | MJ Amplify Alternative Harvest ETF | 22.30 | +1.64% | -37.71% | $95.5M | 1.12% | -26.18% |
Market data delayed approximately 15–20 minutes unless otherwise indicated. Rankings rank measurable characteristics; they are never a recommendation to buy or sell anything.